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Journal of Tropical Pediatrics Advance Access published online on December 3, 2008
Journal of Tropical Pediatrics, doi:10.1093/tropej/fmn101
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© The Author [2008]. Published by Oxford University Press. All rights reserved. For Permissions, please email: journals.permissions@oxfordjournals.org

Role of Astrovirus in Intussusception in Nigerian infants

M. Aminua *, E. A. Amehb, A. Geyerc *, M. D. Esonad *, M. B. Taylore and A. D. Steelef *

aDepartment of Microbiology, Faculty of Science, Ahmadu Bello University, Zaria, Nigeria
bDivision of Pediatric Surgery, Ahmadu Bello University Teaching Hospital, Zaria, Nigeria
cMRC/MEDUNSA Diarrhoeal Pathogens Research Unit, University of Limpopo, Medunsa Campus, Pretoria, South Africa
dGastroenteritis and Respiratory Viruses Laboratory Branch, Division of Viral Diseases, Centers for Disease Control and Prevention, Atlanta, GA, USA
eDepartment of Medical Virology, University of Pretoria/National Health Laboratory Service, Pretoria, South Africa
fPATH, 1455 Leary Way NW, Seattle, WA 98107, USA

Correspondence: Maryam Aminu, Department of Microbiology, Faculty of Science, Ahmadu Bello University, Zaria, Nigeria. Tel.: +234 803 3287031. E-mail <maryamaminu{at}yahoo.com>.


  Abstract

Intussusception (IS) is a form of intestinal obstruction in which a segment of the bowel prolapses into a more distal segment. Viral infections, mostly adenovirus, enteroviruses, human herpesvirus and Epstein–Barr virus are reported in 20–50% of childhood cases of IS. Between January and July 2004, six stool specimens collected from infants 0- to 8-months old diagnosed and admitted for IS were investigated for the presence of rotavirus, astrovirus and adenovirus antigens. Astrovirus antigen was detected in three of the six stool specimens by enzyme immune assay (EIA) and confirmed in two specimens by reverse transcription–polymerase chain reaction (RT–PCR). Rotavirus, non-enteric adenovirus and astrovirus were detected by EIA, as mixed infections in a single specimen. The rotavirus strain revealed a SGI+II, mixed G1G2G8P[6] genotype and had no visible electrophoretic profile. A larger study is needed to determine the extent of involvement of astroviruses in IS in infants and the virus should be included in studies investigating the aetiology of IS.

Key Words: intussusception • infants • astroviruses

*Members of African Rotavirus Network.


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