Skip Navigation



Journal of Tropical Pediatrics Advance Access published online on September 11, 2008
Journal of Tropical Pediatrics, doi:10.1093/tropej/fmn074
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow All Versions of this Article:
55/1/60    most recent
fmn074v1
Right arrow E-letters: Submit a response
Right arrow Alert me when this article is cited
Right arrow Alert me when E-letters are posted
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrowRequest Permissions
Google Scholar
Right arrow Articles by Murphy, R. A.
Right arrow Articles by McIntosh, K.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Murphy, R. A.
Right arrow Articles by McIntosh, K.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

© The Author [2008]. Published by Oxford University Press. All rights reserved. For Permissions, please email: journals.permissions@oxfordjournals.org

Case Report

Development of Dual-class Antiretroviral Drug Resistance in a Child Coinfected with HIV and Tuberculosis: A Case Report from KwaZulu-Natal, South Africa

Richard A. Murphya, Holly Franceb, Henry Sunpathc, Michelle L. Gordond, Vincent C. Marconie, Daniel R. Kuritzkesf and Kenneth McIntoshg

aDivision of Infectious Diseases, Massachusetts General Hospital, and Brigham and Women's Hospital, Boston, MA, USA
bSinikithemba Clinic, McCord Hospital, Durban, South Africa
cDepartment of Medicine, McCord Hospital, Durban, South Africa
dDepartment of Virology, Nelson Mandela School of Medicine, University of KwaZulu-Natal, Durban, South Africa
eTri-Service AIDS Clinical Consortium, Wilford Hall USAF Medical Center, Lackland AFB, San Antonio, TX, USA
fSection of Retroviral Therapeutics, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA
gDivision of Infectious Diseases, Children's Hospital, Boston, MA, USA

Correspondence: Richard A. Murphy, Medecins Sans Frontieres USA, New York, NY, USA. E-mail <richard.murphy{at}newyork.msf.org>.


  Abstract

The treatment of concurrent HIV and tuberculosis (TB) in children <3 years of age has not been well-studied and is complicated by potential drug–drug interactions. The recommended antiretroviral therapy (ART) in coinfected children in South Africa consists of full-strength ritonavir, lamivudine and stavudine. We report on a child initiated on this regimen, during concurrent TB treatment, who promptly developed an adverse reaction, virologic failure and dual-class antiretroviral drug resistance, compromising subsequent salvage ART.


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?




Disclaimer: Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.