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Journal of Tropical Pediatrics Advance Access published online on May 22, 2008
Journal of Tropical Pediatrics, doi:10.1093/tropej/fmn039
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© The Author [2008]. Published by Oxford University Press. All rights reserved. For Permissions, please email: journals.permissions@oxfordjournals.org

Challenges in the Identification and Treatment of PANDAS: A Case Series

Abdul Azim Mabrouka and Valsamma Eapenb,c

aDepartment of Pediatrics, School Health Services, Al Ain
bDepartment of Psychiatry, Faculty of Medicine, UAE University, Al Ain
cInfant, Child and Adolescent Psychiatry, University of New South Wales, Sydney, Australia

Correspondence: Prof. V. Eapen, Professor of Infant Child and Adolescent Psychiatry, UNSW, ICAMHS, Mental Health Centre, L1, Liverpool Hospital, Elizabeth Street, Liverpool, NSW 2170. Tel.: 02-96164364; Fax: 02-96012773. E-mail <valsa_eapen{at}hotmail.com>.


  Abstract

Paediatric autoimmune neuropsychiatric disorder associated with streptococcal infection (PANDAS), is characterized by childhood-onset obsessive-compulsive disorder (OCD) and Tic disorder that has been found to have a post infectious autoimmune-mediated etiology, where the onset and subsequent exacerbations of symptoms is temporally related to group A beta-hemolytic streptococci (GABHS) infection. In addition to the use of anti-tic and antiobsessional agents, the use of Penicillin during the acute phase and for prophylaxis, tonsillectomy, immunomodulatory therapies such as plasma exchange and intravenous immunoglobulin, etc. have all been reported to improve the symptoms. We describe five cases of neuropsychiatric symptoms triggered by streptococcal infection in an Arab population and highlight the challenges faced by clinicians in the identification and management of PANDAS.

Key Words: PANDAS • OCD • Tics • neuropsychiatric symptoms • streptococcal infection


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