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Journal of Tropical Pediatrics Advance Access published online on March 4, 2008
Journal of Tropical Pediatrics, doi:10.1093/tropej/fmm096
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© The Author [2008]. Published by Oxford University Press. All rights reserved. For Permissions, please email: journals.permissions@oxfordjournals.org

Norovirus and Sapovirus Infections among Children with Acute Gastroenteritis in Ho Chi Minh City during 2005–2006

Tuan Anh Nguyena,b, LePhuc Hoangc, Le Duc Phamc, Kim Trong Hoanga,b, Shoko Okitsua,d, Masashi Mizuguchia and Hiroshi Ushijimaa,d,e

aDepartment of Developmental Medical Sciences, Institute of International Health, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan
bDepartment of Pediatrics, University of Medicine and Pharmacy at Ho Chi Minh City, Ho Chi Minh City, Vietnam
cChildren's Hospital 1, Ho Chi Minh City, Vietnam
dAino Health Research Center, Aino University, Tokyo, Japan
eThe International University of Kagoshima, Kagoshima, Japan

Correspondence: Hiroshi Ushijima, MD, PhD, Aino Health Research Center, Aino University 2-17-3 Shibuya, Shibuya-ku, Tokyo 150-0002, Japan. E-mail: < ushijima-hiroshi{at}jcom.home.ne.jp>.


  Abstract

A molecular epidemiological study on common diarrheal viruses was conducted in a children's hospital in Ho Chi Minh City between December 2005 and November 2006. Fecal samples were collected from 502 pediatric patients with acute gastroenteritis, and were screened for the presence of norovirus (NoV) and sapovirus (SaV). NoVs GII and SaVs were detected in 6.4% and 1.2% specimens, respectively, while there was no NoV GI found among studied samples. NoVs could be identified through the year, except in April and July, with the peak of detection rate (62.5%) during the rainy season. Conversely, four out of six (66.7%) of the SaV strains were identified during the dry season. Patients aged between 6 and 23 months were found to be more infected by NoVs. The overall mean severity score of norovirus-positive patients was 9.8 ± 3.6, and no significant difference of severity scores among patients belonged to different age groups, gender and place of living. The results of phylogenetic analysis showed the diversity of caliciviruses circulating in the area, and various types of recombination were identified among NoVs and SaVs detected. These results provide important information on calicivirus infections among Vietnamese children.

Key Words: norovirus • sapovirus • clinical manifestations • recombinant • Vietnam


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