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Journal of Tropical Pediatrics Advance Access published online on May 29, 2007
Journal of Tropical Pediatrics, doi:10.1093/tropej/fmm035
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© The Author [2007]. Published by Oxford University Press. All rights reserved. For Permissions, please email: journals.permissions@oxfordjournals.org

Role of Steroids on the Clinical Course and Outcome of Meconium Aspiration Syndrome—A Randomized Controlled Trial

Sriparna Basua, Ashok Kumara, B. D. Bhatiaa, K. Satyaa and T. B. Singhb

aDivision of Neonatology and bDivision of Biostatistics, Department of Pediatrics, Institute of Medical Sciences, Banaras Hindu University, Varanasi, India

Correspondence: Dr Sriparna Basu, Department of Pediatrics, Institute of Medical Sciences, Banaras Hindu University, Varanasi 221005, India. E-mail: < drsriparnabasu{at}rediffmail.com>.


  Abstract

Background: Meconium aspiration syndrome (MAS) is one of the major causes of severe respiratory distress in the newborn and there is no uniform protocol of management after the development of MAS.

Objective: The objective of the study was to determine whether systemic and inhalational steroid therapy can alter the clinical course of MAS and improve the outcome without causing any serious adverse effects.

Methods: A randomized controlled trial was conducted in three groups of MAS over a period of 1 year. Group A (n = 33) served as controls, Group B (n = 34) received systemic methyl prednisolone and Group C (n = 32) received nebulized budesonide both for a period of 7 days starting after 24 h of age. Details of clinical progress were noted during the hospital stay. Follow up for a minimum period of 3 months was done in all. Data were analysed by SPSS 10 software. Student's t and ANOVA were used to assess statistical significance.

Results: Patient profile was similar in all the three groups. Period of oxygen dependency and duration of hospital stay was significantly less in the steroid treated groups. Similarly full enteral feeding and radiological clearance of chest could be achieved earlier in groups B and C. No difference between the steroid treated groups could be appreciated by Student's Newman Kuel (SNK) test. Development of sepsis was similar in all the groups and no serious adverse effects were noted in steroid treated groups.

Conclusion: Steroids are effective in the management of MAS and route of administration does not have a bearing on the efficacy.

Key Words: budesonide • meconium aspiration syndrome • methylprednisolone • neonate • steroids.


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