Skip Navigation



Journal of Tropical Pediatrics Advance Access published online on December 13, 2006
Journal of Tropical Pediatrics, doi:10.1093/tropej/fml077
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow All Versions of this Article:
53/1/32    most recent
fml077v1
Right arrow E-letters: Submit a response
Right arrow Alert me when this article is cited
Right arrow Alert me when E-letters are posted
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrowRequest Permissions
Google Scholar
Right arrow Articles by Aghamohammadi, A.
Right arrow Articles by Moin, M.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Aghamohammadi, A.
Right arrow Articles by Moin, M.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

© The Author [2006]. Published by Oxford University Press. All rights reserved. For Permissions, please email: journals.permissions@oxfordjournals.org

Mortality and Morbidity in Common Variable Immunodeficiency

Asghar Aghamohammadia,b, Nima Pouladib, Nima Parvaneha, Mehdi Yeganehb, Masoud Movahedia, Mohamad Gharagoloua, Zahra Pourpakb, Nima Rezaeib, Ali Salavatia,c, Sina Abdollahzadea,c and Mostafa Moina,b

aChildren's Medical Center, Department of Pediatrics, bImmunology, Asthma and Allergy Research Institute, and cStudents’ Scientific Research Center (SSRC), Vice Chancellor for Research, Tehran University of Medical Sciences, Tehran, Iran

Correspondence: Asghar Aghamohammadi, Division of Clinical Immunology of Children's Medical Center, Tel.: +98 2166935855; Fax: +98 2166428995. E-mail < aghamohammadi{at}sina.tums.ac.ir>.


  Abstract

Common variable immunodeficiency (CVID) is a heterogeneous group of disorders, characterized by hypogammaglobulinemia, defective specific-antibody production resulting in recurrent bacterial infections. Delay in diagnosis and inadequate treatment result in increased irreversible complications and mortality. To determine persistent morbidities, mortality rate and survival in Iranian patients with CVID, hospital records of 72 (39 males and 33 females) diagnosed CVID patients were reviewed. Probabilities of survival after diagnosis of CVID were estimated from Kaplan–Meier life tables.

Studied patients were enrolled over a 20-year period (1984–2005). The most commonly observed complication was bronchiectasis (24 cases), followed by splenomegaly, intestinal villous atrophy (11 cases), and failure to thrive (10 cases). Post-diagnosis survival was estimated as 65% for the first 6.5 years, which remains the same until 14 years after diagnosis when the survival curve drops to nearly 45%. The mortality rate among patients who had no regular visits and did not receive periodical IVIG was more remarkable when compared with those who had been followed up timely (p-value = 0.001).The most common cause of death was respiratory failure. Based on our observation, it can be highlighted that all patients with CVID, even under regular immunoglobulin replacement, need close monitoring for early detection of complications and introduction of appropriate management.


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?


This article has been cited by other articles:


Home page
 BloodHome page
H. Chapel, M. Lucas, M. Lee, J. Bjorkander, D. Webster, B. Grimbacher, C. Fieschi, V. Thon, M. R. Abedi, and L. Hammarstrom
Common variable immunodeficiency disorders: division into distinct clinical phenotypes
Blood, July 15, 2008; 112(2): 277 - 286.
[Abstract] [Full Text] [PDF]


Disclaimer: Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.