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Journal of Tropical Pediatrics Advance Access published online on December 10, 2006
Journal of Tropical Pediatrics, doi:10.1093/tropej/fml068
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© The Author [2006]. Published by Oxford University Press. All rights reserved. For Permissions, please email: journals.permissions@oxfordjournals.org

Oxidant and Non-enzymatic Antioxidant Status in Measles

Mustafa Cemeka, Semiha Dedeb, Fahri Bayirogluc, Hüseyin Çaksend, Fatma Cemekd and Nihat Mertb

aDepartment of Chemistry (Biochemistry Division), Faculty of Science and Arts, Afyon Kocatepe University, Afyon, Turkey
Departments of bBiochemistry and cPhysiology, Faculty of Veterinary Medicine, Yüzüncü Y{iota}l University, Van, Turkey
dDepartment of Pediatrics, Faculty of Medicine, Yüzüncü Y{iota}l University, Van, Turkey

Correspondence: Dr Mustafa Cemek, Afyon Kocatepe Üniversitesi, Fen Edebiyat Fakültesi, Kimya Bölümü, Biyokimya AD, ANS Kampüsü Afyon – Turkey. Tel.: 0 + 90-(272) 228 13 12; Fax: 0 + 90-(272) 228 12 35. E-mail < mcemek{at}yahoo.com>.


  Abstract

Measles is a highly contagious viral disease of childhood associated with serious complications and significant morbidity and mortality. In the present study, antioxidant and oxidant status was investigated in children with measles. Our aim was to evaluate the possible changes in non-enzymatic antioxidant levels and their relationship to the oxidative stress in measles. According to our knowledge, there are no data about the blood levels of malondialdehyde (MDA), reduced glutathione (GSH) and vitamin C in measles. We measured the whole blood MDA (as a marker of lipid peroxidation) and GSH, and serum ß-carotene, retinol, {alpha}-tocopherol and ascorbic acid levels in all subjects.

There was a statistically significant difference between the groups for all parameters (p < 0.05). Non-enzymatic antioxidant status was found to be decreased but, lipid peroxidation was increased in the study group. As a conclusion, these findings suggested that oxidant and antioxidant defence system were altered in children with measles.

Key Words: malondialdehyde • reduced glutathione • antioxidant vitamins • measles • child.


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