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Journal of Tropical Pediatrics Advance Access published online on December 10, 2006
Journal of Tropical Pediatrics, doi:10.1093/tropej/fml060
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© The Author [2006]. Published by Oxford University Press. All rights reserved. For Permissions, please email: journals.permissions@oxfordjournals.org

Oxidative Stress in Neonatal Hyperbilirubinemia

Ashok Kumara, Pragya Panta, Sriparna Basua, G. R. K. Raob and H. D. Khannac

aDepartments of Pediatrics,bBiochemistry and cBiophysics, Institute of Medical Sciences, Banaras Hindu University, Varanasi – 221 005, India

Correspondence: Dr Ashok Kumar, Reader, Department of Pediatrics, Institute of Medical Sciences, Banaras Hindu University, Varanasi, 221005, India. E-mail < ashokkumar_bhu{at}hotmail.com>.


  Abstract

We investigated the role of bilirubin as an antioxidant in neonatal hyperbilirubinemia (NNH) by measuring malondialdehyde (MDA) levels, a marker of oxidative stress and key antioxidant enzymes viz., superoxide dismutase (SOD), catalase and glutathione peroxidase (GPx) in otherwise healthy 70 term newborns with NNH and 20 control newborns without jaundice. Jaundiced newborns had significantly lower MDA but higher SOD, catalase and GPx levels. Furthermore, plasma bilirubin showed significant negative correlation with MDA but positive correlation with antioxidant enzyme activities. It is concluded that NNH is associated with lower oxidative stress.


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