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Journal of Tropical Pediatrics Advance Access published online on March 10, 2006
Journal of Tropical Pediatrics, doi:10.1093/tropej/fml001
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© The Author [2006]. Published by Oxford University Press. All rights reserved. For Permissions, please email: journals.permissions@oxfordjournals.org

Original Papers

Recurrent Salmonella Bacteremia in Interleukin-12 Receptor {beta}1 Deficiency

Metehan Ozen 1 *, Mehmet Ceyhan 2, Ozden Sanal 3, Mehmet Bayraktar 4, and Lütfiye Mesci 3

1 Inonu University, Faculty of Medicine, Division of Pediatric Infectious Disease, Malatya, Turkey
2 Hacettepe University, Faculty of Medicine, Unit of Pediatric Infectious Disease, Ankara, Turkey
3 Hacettepe University, Faculty of Medicine, Unit of Pediatric Immunology, Ankara, Turkey
4 Inonu University, Faculty of Medicine, Department of Clinical Microbiology, Malatya, Turkey

* To whom correspondence should be addressed.
Metehan Ozen, E-mail: metehanoz{at}yahoo.com


  Abstract

Interleukin-12 receptor {beta}1 (IL12RB1) deficiency causes vulnerability to poorly virulent mycobacteria and nontyphoid Salmonella species. We describe a 2.5 year-old girl with IL12RB1 deficiency, caused by a homozygous mutation in this gene, who presented with recurrent bacteremia caused by Salmonella spp.


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