Skip Navigation



Journal of Tropical Pediatrics Advance Access published online on December 8, 2005
Journal of Tropical Pediatrics, doi:10.1093/tropej/fmi103
This Article
Right arrow Full Text (Rapid PDF)
Right arrow All Versions of this Article:
52/3/206    most recent
fmi103v1
Right arrow E-letters: Submit a response
Right arrow Alert me when this article is cited
Right arrow Alert me when E-letters are posted
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrowRequest Permissions
Google Scholar
Right arrow Articles by Onkar Shivraj, S.
Right arrow Articles by Baveja, U. K.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Onkar Shivraj, S.
Right arrow Articles by Baveja, U. K.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

© The Author [2005]. Published by Oxford University Press. All rights reserved. For Permissions, please email: journals.permissions@oxfordjournals.org

Article

Role of HCV Coinfection Towards Disease Progression and Survival in HIV-1 Infected Children: A Follow-Up Study of 10 Years

Swami Onkar Shivraj 1, Debasish Chattopadhya 2 *, Gurprit Grover 1, Ashok Kumar 3, and Usha K. Baveja 2

1 Department of Statistics, University of Delhi, Delhi, India
2 AIDS Reference Laboratory, Division of AIDS, National Institute of Communicable Diseases, 22-Sham Nath Marg, Delhi, India
3 Clinical Immunology Services, Department of Medicine, All India Institute of Medical Sciences, New Delhi, India

* To whom correspondence should be addressed.
Debasish Chattopadhya, E-mail: dchattopadhya{at}yahoo.co.in


  Abstract

The present study was taken up to evaluate the pattern of disease progression and survival in a group of HIV-1 positive children, coinfected with HCV infection (n=25) in comparison to those without such coinfection (n=23). There was a significant negative correlation between the rate of decline of the CD4 + T cell percentage and the duration of the AIDS-free interval in most (80.0 per cent) of the HCV seropositive children showing such decline (r=-0.588; p=0.005). The HCV seropositive children had twofold higher risk of progression to development of AIDS than HCV seronegatives (RR=2.51; 95 per cent CI:1.34-4.69; p=0.004). There was a significant negative correlation between the rate of decline of CD4 + T cell percentage and overall survival duration for HCV seropositive group (r=-0.609; p=0.003). Moreover, children coinfected with HCV had more than twofold higher risks of death than those without HCV (RR=2.39; 95 per cent CI:1.17-4.89; p<0.01). It appears that HCV infection may be an important contributor to the rapid disease progression and increase in mortality in HCV-HIV-1 coinfected children of thalassemia major.


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?


This article has been cited by other articles:


Home page
 J R Soc InterfaceHome page
I. M Cattadori, R. Albert, and B. Boag
Variation in host susceptibility and infectiousness generated by co-infection: the myxoma-Trichostrongylus retortaeformis case in wild rabbits
J R Soc Interface, October 22, 2007; 4(16): 831 - 840.
[Abstract] [Full Text] [PDF]


Disclaimer: Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.