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Journal of Tropical Pediatrics Advance Access published online on January 26, 2005
Journal of Tropical Pediatrics, doi:10.1093/tropej/fmh089
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© Oxford University Press 2005; all rights reserved

Original Papers

Carnitine Levels in Neonatal Hypoxia

Halit Çam 1*, Behçet Yildirim 2, Ahmet Aydin 1, and Aysu Say 1

1 Department of Pediatrics, Istanbul University, Cerrahpasa Medical Faculty
2 Department of Pediatrics, Zeynep Kamil Maternal and Children Hospital

* To whom correspondence should be addressed.
Halit Çam, E-mail: hacam{at}istanbul.edu.tr


  Abstract

Background: The aim of this study is to determine carnitine levels in hypoxic-ischemiac neonates.

Methods: Total and free carnitine levels were measured in 20 normal term neonates and 20 term neonates who were diagnosed as hypoxia-ischemia.

Results: Both total carnitine levels (43.7 ± 10.0 µg/dl vice 27.8 ± 11.8 µg/dl, p<0.0001) and free carnitine levels (28.0 ± 8.8 vice 13.2 ± 6.8 µg/dl, p<0.0001) were lower in the hypoxic-ischemic group). Additionally acyl/total carnitine ratio was higher in the asphyxic group (0.33 ± 0.20 vice 0.56 ± 0.24, p<0.0001).

Conclusions: The findings of this study show that neonates with hypoxia-ischemia suffer carnitine deficiency.


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