Skip Navigation


Journal of Tropical Pediatrics Advance Access originally published online on March 10, 2009
Journal of Tropical Pediatrics 2009 55(5):318-323; doi:10.1093/tropej/fmp016
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow All Versions of this Article:
55/5/318    most recent
fmp016v2
fmp016v1
Right arrow E-letters: Submit a response
Right arrow Alert me when this article is cited
Right arrow Alert me when E-letters are posted
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrowRequest Permissions
Google Scholar
Right arrow Articles by Kiulia, N. M.
Right arrow Articles by Mwenda, J. M.
PubMed
Right arrow PubMed Citation
Right arrow Articles by Kiulia, N. M.
Right arrow Articles by Mwenda, J. M.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

© The Author [2009]. Published by Oxford University Press. All rights reserved. For Permissions, please email: journals.permissions@oxfordjournals.org

Rotavirus Infections among HIV-Infected Children in Nairobi, Kenya

Nicholas M. Kiuliaa, Julia K. Nyaundia, Ina Peenzeb, Atunga Nyachieoa, Rachel N. Musokec, Andrew D. Steeleb and Jason M. Mwendaa

aEnteric Viruses Research Group, Institute of Primate Research, P. O. Box 24481, 00502, Karen, Nairobi, Kenya
bMedical Research Council (MRC), Diarrhoeal Pathogens Research Unit, MEDUNSA Campus, University of Limpopo, P.O. Box 173, MEDUNSA, 0204 Pretoria, South Africa
cKenyatta National Hospital, Department of Pediatrics, P.O. Box 20723, 00202 Nairobi, Kenya

Correspondence: Jason M. Mwenda, Enteric Viruses Research Group, Institute of Primate Research, P. O. Box 24481-00502, Karen, Nairobi, Kenya. Tel.: +254-020-882571-4; Fax: +254-020-882546. E-mail: <jmmathiu{at}yahoo.co.uk>.


  Abstract

Human rotaviruses have emerged as a leading cause of acute diarrhea in children <5 years of age worldwide. Although there are previous reports relating to various aspects of rotaviruses, there is limited data on the involvement of rotavirus infection in HIV-infected children. We therefore evaluated the importance of rotavirus infections in HIV-related diarrhea in Kenyan children. Fecal samples were collected from a total of 207 children during the period February 1999 to June 2000 and screened for HRV antigen by enzyme-linked immunosorbent assay (ELISA). Positive samples were analyzed by VP6 subgroup specificity assay, by polyacrylamide gel electrophoresis (PAGE) and reverse transcriptase/polymerase chain reaction (RT–PCR). Fourteen percent (29/207) of the samples were positive. HIV-seropositive children with diarrhea were more likely than their counterparts without diarrhea to have rotaviruses [23.3% (10/43) versus 2.9% (2/70); p = 0.0001]. Rotavirus strain G3P[6] was predominant. These results indicate that rotavirus is an important viral etiological agent causing diarrhea in HIV-seropositive children.

Key Words: rotavirus • HIV • genotypes • vaccine


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?




Disclaimer: Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.