Skip Navigation


Journal of Tropical Pediatrics Advance Access originally published online on January 21, 2009
Journal of Tropical Pediatrics 2009 55(5):290-296; doi:10.1093/tropej/fmn118
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow All Versions of this Article:
55/5/290    most recent
fmn118v1
Right arrow E-letters: Submit a response
Right arrow Alert me when this article is cited
Right arrow Alert me when E-letters are posted
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Related articles in J Trop Pediatr
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrowRequest Permissions
Google Scholar
Right arrow Articles by Kupka, R.
Right arrow Articles by Fawzi, W. W.
PubMed
Right arrow PubMed Citation
Right arrow Articles by Kupka, R.
Right arrow Articles by Fawzi, W. W.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

© The Author [2009]. Published by Oxford University Press. All rights reserved. For Permissions, please email: journals.permissions@oxfordjournals.org

Patterns and Predictors of CD4 T-cell Counts Among Children Born to HIV-infected Women in Tanzania

Roland Kupkaa,b, Gernard I. Msamangac, Said Aboudd, Karim P. Manjie, Christopher Dugganf and Wafaie W. Fawzia,g

aDepartment of Nutrition, Harvard School of Public Health, Boston, MA, USA
bUnited Nations Children's Fund, Regional Office for West and Central Africa, Dakar, Senegal
cDepartment of Community Health, Muhimbili University of Health and Allied Sciences, Dar es Salaam, Tanzania
dDepartment of Microbiology and Immunology, Muhimbili University of Health and Allied Sciences, Dar es Salaam, Tanzania
eDepartment of Pediatrics and Child Health, Muhimbili University of Health and Allied Sciences, Dar es Salaam, Tanzania
fDivision of Gastroenterology and Nutrition, Children's Hospital, Boston, MA, USA
gDepartment of Epidemiology, Harvard School of Public Health, Boston, MA, USA

Correspondence: Roland Kupka, DSc, Department of Nutrition, Harvard School of Public Health, 665 Huntington Avenue, Boston, MA 02115, USA. E-mail <rkupka{at}post.harvard.edu>


  Abstract

We assessed age-specific CD4 T-cell counts and their determinants among Tanzanian children born to HIV-infected mothers to address a major research gap. A total of 474 HIV-uninfected and 69 HIV-infected children were followed until age of 12 months. Maternal predictors were measured during pregnancy and child predictors at birth and throughout the follow up. Child CD4 T-cell counts were evaluated at the age of 3 months and subsequent 3-month intervals; they decreased linearly among HIV-infected (β = –8 cells per week; 95% CI –12 to –4; P = 0.0003) and increased linearly among HIV-uninfected children (β = 4 cells/week; 95% CI 2–7; P = 0.0008). Decreased child counts were predicted by low child anthropometry, maternal HIV stage ≥2, and maternal mid-upper arm circumference <27 cm among HIV-infected children; and by weight-for-height <–2 z-score, maternal HIV stage ≥2, maternal erythrocyte sedimentation rate <81 mm/h and maternal haemoglobin <8.5 g/dl among HIV-uninfected children. The maternal and child predictors described may serve as intervention targets among HIV-exposed children.


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?

Related articles in J Trop Pediatr:

In this Issue October 2009

J Trop Pediatr 2009 55: i. [Full Text]  





Disclaimer: Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.