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Journal of Tropical Pediatrics Advance Access originally published online on February 8, 2009
Journal of Tropical Pediatrics 2009 55(2):116-121; doi:10.1093/tropej/fmn117
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© The Author [2009]. Published by Oxford University Press. All rights reserved. For Permissions, please email: journals.permissions@oxfordjournals.org

Randomised Controlled Study-efficacy of Clonidine versus Carbamazepine in Children with ADHD

Vrinda Nair and S. Mahadevan

Department of Pediatrics, JIPMER Hospital, Pondicherry, India

Correspondence: Dr Vrinda Nair, Thoppil house, Sachivothamapuram, Kurichy, Kottayam, Kerala. Tel.: +91 0481 2432382. Fax.: +91 0473 4252865 E-mail <vrindanairmd{at}gmail.com>.


  Abstract

Background: Attention deficit hyperactivity disorder (ADHD) is one of the most common childhood psychiatric disorder with a prevalance of 8–12%. Even though psychostimulants remain the treatment of choice, its cost and availability in developing countries limits the usage of the drug. In view of free availability and low cost, a Randomized controlled study was carried out using two second line drugs (clonidine and carbamazepine) in a tertiary care hosipital, Pondicherry, South India.

Objective: To compare the efficacy of clonidine and carbamazepine in children with ADHD.

Method: With approval of ethics committee, a prospective, Double-blind, Randomized controlled study of clonidine and carbamazepine was conducted with 50 children with ADHD (age group 4–12 years), over a period of 2 years (2005–07) in a tertiary care hosipital, Pondicherry, South India.

Results: Clonidine was effective in improving the hyperactivity and impulsivity symptoms in children with ADHD as compared to carbamazepine. Statistical significant improvement was not noted with respect to inattention symptoms and other comorbid conditions.

Conclusion: Clonidine can be a safer and cheaper alternative in treatment of children with ADHD, with a predominant effect on their hyperactivity and impulsivity symptoms.

Key Words: pyschiatric and psychology • health care • chemicals and drugs


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J Trop Pediatr 2009 55: i. [Full Text]  





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