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Journal of Tropical Pediatrics Advance Access originally published online on September 17, 2007
Journal of Tropical Pediatrics 2008 54(1):74-77; doi:10.1093/tropej/fmm082
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© The Author [2007]. Published by Oxford University Press. All rights reserved. For Permissions, please email: journals.permissions@oxfordjournals.org

Brief Reports

Resetting the Detection Level of Cord Blood Thyroid Stimulating Hormone (TSH) for the Diagnosis of Congenital Hypothyroidism

O. O. Ogunkeyea, A. I. Rolugaa and F. A. Khanb

aLaboratory Departments, King Khalid Hospital, Najran, Kingdom of Saudi Arabia
bNajran General Hospital, Najran, Kingdom of Saudi Arabia

Correspondence: Dr O. O. Ogunkeye, Department of Chemical Pathology, University of Jos, P.M.B. 2084, Jos, Nigeria. E-mail < obaogunkeye{at}hotmail.com>.


  Abstract

An appraisal of a 17-year primary thyroid stimulating hormone (TSH) screening programme for the detection of congenital hypothyroidism was carried out to establish the reference interval of cord blood TSH in unaffected infants; the mean cord blood TSH concentration of affected infants and the incidence of congenital hypothyroidism in the Najran province of Saudi Arabia. Our findings show a reference interval of cord blood TSH of 2.0–16.8 mU/l in unaffected infants; a mean cord blood TSH concentration of 399 mU/l in affected infants; a false positive rate for the diagnosis of at-risk infants of 1.02% and a congenital hypothyroidism incidence rate of 34/100 000 (1 : 2931) live births. These findings suggest that there is a need to reset the cord blood TSH concentration for the detection of at-risk infants. We suggest that the detection level of cord blood TSH for the recognition of at-risk infants can be set at 90 mU/l rather than the recommended level of 30 mU/l. This should reduce the false positive rate for detection of infants at risk of congenital hypothyroidism.


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