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Journal of Tropical Pediatrics Advance Access originally published online on November 4, 2007
Journal of Tropical Pediatrics 2008 54(1):6-13; doi:10.1093/tropej/fmm061
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© The Author [2007]. Published by Oxford University Press. All rights reserved. For Permissions, please email: journals.permissions@oxfordjournals.org

Pattern of Malaria-specific T-Cell Responses in a Cohort of Ugandan Children

Isaac Ssewanyanaa, Christopher Pietrasb, Chris A. R. Bakerc, Frehd Nghaniaa, Norman G. Jonesc, Philip J. Rosenthalb, Grant Dorseyb and Huyen Caoc

aJoint Clinical Research Centre, Kampala, Uganda, bUniversity of California, San Francisco, USA, and cCalifornia Department of Health Services, Richmond, USA

Correspondence: Dr Huyen Cao, California Department of Public Health, Viral and Rickettsial Disease Laboratory, 850 Marina Bay Parkway, Richmond, CA 94804, USA. Tel.: (510) 307-8913; Fax: (510) 307-8601. E-mail < Huyen.Cao{at}cdph.ca.gov>.


  Abstract

Malaria is the leading cause of morbidity and mortality in children in Uganda. The mechanisms whereby malaria parasites are eliminated, or how they may avoid the immune response remain poorly understood. We examined malaria-specific T-cell responses in a well-characterized cohort of African children in an endemic area where malaria transmission occurs throughout the year. In studies of asymptomatic children, we found a low frequency of malaria-specific T-cell responses (15/117), and these appeared to be clustered in older children (≥4 years old). Both CD4– and CD8-mediated T-cell responses were detected against circumsporozoite surface protein (CSP) and merozoite surface protein-1 (MSP-1). The presence of these T cells did not correlate with the frequency of prior episodes of parasitemia and 5 out of the 15 responders had no documented parasitemia within 8–12 months prior to immunologic evaluation. Our data supports focusing on high-risk children in future preventive vaccination efforts to ensure the generation and maintenance of effective anti-malarial cellular immune responses.


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