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Journal of Tropical Pediatrics Advance Access originally published online on March 22, 2006
Journal of Tropical Pediatrics 2006 52(5):372-375; doi:10.1093/tropej/fml013
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© The Author [2006]. Published by Oxford University Press. All rights reserved. For Permissions, please email: journals.permissions@oxfordjournals.org

Brief Reports

Lipid Peroxidation and Antioxidants in Neonatal Septicemia

Kapil Kapoor, Sriparna Basu, B. K. Das and B. D. Bhatia

Division of Neonatology, Department of Pediatrics, Institute of Medical Sciences, Banaras Hindu University, Varanasi 221 005, India

Correspondence: Dr Sriparna Basu, Department of Pediatrics, Institute of Medical Sciences, Banaras Hindu University, Varanasi – 221 005, India. E-mail < drsriparnabasu{at}rediffmail.com>.

Free radicals have been implicated in the pathogenesis of neonatal septicemia. The present study was planned to estimate the lipid peroxidation and antioxidant status in neonatal septicemia. The study was done to evaluate the lipid peroxidation and antioxidant status, both enzymatic and non-enzymatic in neonates with septicemia. This prospective study included 44 septicemic babies as cases and a group of 84 matched healthy babies formed the control. Malondialdehyde (MDA), Superoxide dismutase (SOD), Glutathione peroxidase (GTPx), Catalase, Uric acid (UA) and Albumin (Alb) were estimated in the serum and compared between the groups. The statistical analysis was done by using SPSS-10 software. Neonates with septicemia had significantly higher levels of MDA, SOD, GTPx, and Catalase, while the levels of UA and Alb were significantly lower as compared to controls (p<0.001). Significantly elevated levels of MDA (p<0.05) and depressed levels of UA (p<0.001) were found in babies with late onset sepsis. Neonates who ultimately succumbed had significantly elevated levels of MDA, SOD, GTPx and Catalase, whereas levels of UA and Alb were significantly depressed (p<0.001). Neonates with sepsis are handicapped in terms of their defense mechanism against free radicals. The utility of supplementation of antioxidant enzymes in neonates with septicemia needs further evaluation.


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