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Journal of Tropical Pediatrics Advance Access originally published online on January 26, 2005
Journal of Tropical Pediatrics 2005 51(2):106-108; doi:10.1093/tropej/fmh089
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© Oxford University Press 2005; all rights reserved

Original Papers

Carnitine Levels in Neonatal Hypoxia

Halit Çam1, Behçet Yildirim2, Ahmet Aydin1 and Aysu Say2

1 Department of Pediatrics, Istanbul University, Cerrahpasa Medical Faculty, 2 Department of Pediatrics, Zeynep Kamil Maternal and Children Hospital

Halit Çam, Cerrahpasa Tip Fakültesi, Çocuk Sagligi ve Hastaliklari Anabilim Dali, Cerrahpasa-Istanbul, Turkey. E-mail <hacam{at}istanbul.edu.tr>.

Background: The aim of this study is to determine carnitine levels in hypoxic–ischemiac neonates.

Methods: Total and free carnitine levels were measured in 20 normal term neonates and 20 term neonates who were diagnosed as hypoxia–ischemia.

Results: Both total carnitine levels (43.7 ± 10.0 µg/dl vice 27.8 ± 11.8 µg/dl, p<0.0001) and free carnitine levels (28.0 ± 8.8 vice 13.2 ± 6.8 µg/dl, p<0.0001) were lower in the hypoxic–ischemic group). Additionally acyl/total carnitine ratio was higher in the asphyxic group (0.33 ± 0.20 vice 0.56 ± 0.24, p<0.0001).

Conclusions: The findings of this study show that neonates with hypoxia–ischemia suffer carnitine deficiency.


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