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Journal of Tropical Pediatrics 2004 50(3):149-152; doi:10.1093/tropej/50.3.149
© 2004 by Oxford University Press
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Serum Immunoglobulin E in Idiopathic Nephrotic Syndrome

O. P. MishraA1,, N. IbrahimA1, UshaA2 and B. K. DasA1

A1 Pediatrics, Institute of Medical Sciences, Banaras Hindu University, India A2 Pathology, Institute of Medical Sciences, Banaras Hindu University, India

Serum immunoglobulin E (IgE) and absolute eosinophil count (AEC) were assayed in 48 children with idiopathic nephrotic syndrome and 20 controls. The mean serum IgE (p < 0.001) and AEC (p < 0.05) were significantly raised in active nephrotic syndrome compared with controls. The mean values of IgE and AEC in nephrotic patients were 228.6 and 164.5 per cent of the normal mean, respectively. The serum IgE and AEC were significantly abnormal in all the subgroups (first attack, infrequent, and frequent relapsers), except AEC in infrequent relapses, when compared with the controls. No significant differences in the parameters were observed among the different subgroups of cases. In remission, the mean IgE and AEC were unchanged in comparison with their corresponding values at diagnosis. Thus, the levels are raised not only in active but also in remission, reflecting abnormal immune status even in the disease-free state.

* Correspondence: Dr O. P. Mishra, 12GF, Kabir Colony, P.O. B.H.U. Varanasi – 221 005, India. E-mail <opmpedia{at}yahoo.co.uk>.


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