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Journal of Tropical Pediatrics 2004 50(1):50-53; doi:10.1093/tropej/50.1.50
© 2004 by Oxford University Press
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Brief Report

Congenital Toxoplasmosis in Uberlândia, MG, Brazil

Gesmar Rodrigues Silva Segundo1, Deise Aparecida Oliveira Silva1, José Roberto Mineo1 and Marcelo Simão Ferreira2,

1 Laboratório de Imunologia, Instituto de Ciências Biomédicas, Brazil 2 Serviço de Moléstias Infecciosas, Departamento de Clínica Médica, Faculdade de Medicina, Universidade Federal de Uberlândia, Uberlândia, MG, Brazil

Almost all babies suffering from congenital toxoplasmosis, if undiagnosed and untreated, will develop visual or neurological impairments by adulthood. The aim of this study was to investigate the occurrence of congenital toxoplasmosis in two hospitals from Uberlândia, Brazil. A total of 805 serum samples of cord blood were collected, 500 from public hospital and 305 from private hospital, and all patients answered a questionnaire about pregnancy and newborns. ELISA was accomplished to detect IgG antibodies to Toxoplasma gondii and positive sera were re-tested to verify specific IgM and IgA antibodies in a capture ELISA. Seroprevalence of IgG antibodies against T. gondii was 51.6 per cent in the hospitals, while the frequency of congenital toxoplasmosis was 0.5 per cent, with specific IgM and/or IgA antibodies. The main clinical alteration was chorioretinitis (an inflammatory process of the retina and uveal tract). The high seroprevalence in this population and expressive rate of congenital disease show the requirement of screening programmes for toxoplasmosis during pregnancy.

* Correspondence: Marcelo Simão Ferreira, Rua Goiás 480 apt 500, Cep 38400.027, Uberlândia, MG – Brazil. E-mail <mferreira{at}nanet.com.br>.


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This article has been cited by other articles:


Home page
 J Trop PediatrHome page
C. Gallego-Marin, A. C. Henao, and J. E. Gomez-Marin
Clinical Validation of a Western Blot Assay for Congenital Toxoplasmosis and Newborn Screening in a Hospital in Armenia (Quindio) Colombia
J Trop Pediatr, April 1, 2006; 52(2): 107 - 112.
[Abstract] [Full Text] [PDF]


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