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Journal of Tropical Pediatrics 2002 48(4):239-242; doi:10.1093/tropej/48.4.239
© 2002 by Oxford University Press
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Brief Report

Changing Profile of Retinopathy of Prematurity

Rajiv Aggarwal1, Ashok K. Deorari1, R. V. Azad2, Harsh Kumar2, Dinesh Talwar2, Anita Sethi2 and Vinod K. Paula1

1 Department of Pediatrics, All India Institute of Medical Sciences, New Delhi, India 2 R. P. Centre for Ophthalmic Sciences, All India Institute of Medical Sciences, New Delhi, India

The aim of this study was to determine the evolving trends of retinopathy of prematurity (ROP) at a tertiary neonatal intensive care unit. In an ongoing screening programme for ROP, we estimated the incidence of ROP among at-risk neonates in a tertiary care unit. We compared our data over the last 12 months (1999–2000; period II) to the previously published data (1993–94; period I) to study changes in the spectrum of the disease. The overall incidence of ROP in period II was not significantly different from the incidence in period I (32 vs. 20 per cent, p > 0.05). However, a decreasing trend in the proportion of severe ROP (stage III) from 46 to 21 per cent in the later period was noted. The need for cryotherapy also dropped significantly compared with the earlier period (8 vs. 46 per cent respectively, p < 0.05). On multivariate analysis, apnea (p < 0.001; RR = 12.5; 95 per cent CI, 3.03–50.9; clinical sepsis (p < 0.001; RR = 5.7; 95 per cent CI, 1.6–20.7); and male sex (p < 0.001; RR = 6.3; 95 per cent CI 1.6–25.5) emerged as significant risk factors. Although the incidence of ROP is static, the more severe form of the disease (stage III) is showing a decline. Our data suggests that efficient management of apnea and sepsis may be crucial in further minimizing the risk of ROP.


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 J Trop PediatrHome page
R. Sharma, V. P. Gupta, U. Dhaliwal, and P. Gupta
Screening for Retinopathy of Prematurity in Developing Countries
J Trop Pediatr, February 1, 2007; 53(1): 52 - 54.
[Abstract] [Full Text] [PDF]


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