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Journal of Tropical Pediatrics 2002 48(1):10-14; doi:10.1093/tropej/48.1.10
© 2002 by Oxford University Press
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Procalcitonin: A Marker of Neonatal Sepsis

Füsun Atlihan1, Birsen Akagündüz1, Ferah Genel1, Mustafa Bak1 and Demet Can1

1 Pediatric Department, Dr Behçet Uz Children's Hospital, Ïzmir, Turkey

This study was designed to assess the value of procalcitonin in establishing the diagnosis and evaluating the prognosis of neonatal sepsis. Thirty-four infants with neonatal sepsis were included in the study. Procalcitonin values of the cases with sepsis were (2.21 ± 2.48 ng/ml) significantly higher than the values in the control group (0.71 ± 0.5 ng/ml; p = 0.01). On the 7th day of therapy neonates who had achieved clinical recovery had a significant decrease of procalcitonin levels (0.55 ± 0.27 ng/ml) compared to the initial values (p = 0.001). Initial mean procalcitonin levels of the cases resulting in death were 4.31 ± 3.66 ng/ml. This was significantly higher than the initial values of the patients who had clinical recovery (1.18 ± 1.24 ng/ml; p = 0.02). Procalcitonin is a valuable marker for diagnosis, for evaluating prognosis and response to therapy in neonatal sepsis.


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