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Journal of Tropical Pediatrics 2000 46(4):237-239; doi:10.1093/tropej/46.4.237
© 2000 by Oxford University Press
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Brief report. Neonatal meningitis: mortality, cerebrospinal fluid, and microbiological findings

E Nel

Department of Paediatrics and Child Health, University of Stellenbosch and Tygerberg Hospital, PO Box 19063 7505, Republic of South Africa Tel: 021 938 9219 Fax: 021 938 9138 E-mail: edn@maties.sun.ac.za

This study describes the bacteriology, cerebrospinal fluid (CSF) findings, and mortality of neonatal meningitis over an 11-year period. The minimum incidence of neonatal meningitis at Tygerberg Hospital is 0.72/1000 live births/year. Eighty-eight patients were included in the study. Median birthweight and age at diagnosis were 2320g and 12 days, respectively. CSF culture was positive in 77 (88 per cent), blood culture was positive in 51 (57 per cent), and Gram stain was positive in 58 (66 per cent). The most frequently cultured organisms were Group B Streptococcus, Klebsiella pneumoniae and E. coli. Thirty (34 per cent) patients died, the majority within 72 h after admission. The death rate was significantly increased in babies with a birthweight of less than 1500g (59 per cent). Increased total CSF protein was associated with an increased risk of death. Normal CSF cell count, total CSF protein and CSF glucose were found in six infants.


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This article has been cited by other articles:


Home page
 Arch. Dis. Child. Fetal Neonatal Ed.Home page
P T Heath, N K Nik Yusoff, and C J Baker
Neonatal meningitis
Arch. Dis. Child. Fetal Neonatal Ed., May 1, 2003; 88(3): F173 - F178.
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