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Journal of Tropical Pediatrics 1998 44(4):230-231; doi:10.1093/tropej/44.4.230
© 1998 by Oxford University Press
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Blood Glucose and Serum Insulin Response in Proteinenergy Malnutrition Following Nutritional Rehabilitation

B. K. Das*,, Jayanthy Ramesh*, J. K. Agarwal**, O. P. Mishra* and R. P. Bhatt**

*Department of Pediatrics, Institute of Medical Sciences, Banaras Hindu University Varanasi, India
**Division of Endocrinology, Institute of Medical Sciences, Banaras Hindu University Varanasi, India

Dr B. K. Das, H-26, BDA Rats, Rabindrapuri Extension, BHU Post Office, Varanasi, India

Fifteen children with protein-energy malnutrition and eight healthy children between the ages of 6 months and 60 months were studied for blood glucose and serum insulin levels in the fasting state and 120 minutes following oral glucose load. The measurements were repeated after normalization of the body weight following 6 weeks of nutritional rehabilitation. The fasting blood glucose increased significantly in the post-treatment period and became comparable to the control value. The abnormal blood glucose response to oral glucose load also normalized. The serum insulin level rose significantly (p < 0.001) in the post-treatment period but failed to normalize. The response to oral glucose load was similar. The observed lower insulin response, despite normoglycemia, after 6 weeks of nutritional rehabilitation indicates persistence of hormonal unbalance which may need a longer duration of rehabilitation for full recovery.


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