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Journal of Tropical Pediatrics 1996 42(6):359-361; doi:10.1093/tropej/42.6.359
© 1996 by Oxford University Press
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brief-report

Use of HIV-1 Specific Immunoglobulin G3 as a Serological Marker of Vertical Transmission

S. Madurai*, D. Moodley**, H. M. Coovadia**,, R. A. Bobat**, W. Gopaul*, A. N. Smith* and D. F. York*

*Department of Virology, Faculty of Medicine, University of Natal Durban, South Africa
**Department of Paediatrics and Child Health, Faculty of Medicine, University of Natal Durban, South Africa

Correspondence: Professor H. M. Coovadia, University of Natal, Faculty of Medicine, Department of Paediatrics and Child Health, P.O. Box 17039, Congella, 4013, Durban, Natal, Republic of South Africa

The objective of the study was to indicate HIV infection in infants. The patients were part of a longitudinal cohort of 43 infants born to HIV seropositive mothers. A modified Genelavia EIA primarily directed against HIV envelope proteins was used. An alkaline pbosphatase labelled IgG3 conjugate was substituted in place of the kit conjugate.

HIV specific IgG3 clearance was optimal at 6 months, whilst HIV total antibody was reliable only from age 12 months onwards. At 6 months no detectable IgG3 were found in 91 per cent of uninfected infants where more of these infants had reduced their total HIV antibody titres at the same period.

We confirm that HIV specific IgG3 measurement is a reliable and cost effective means of identifying HIV infected infants from 6 months of age onwards.


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