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Journal of Tropical Pediatrics 1992 38(5):247-251; doi:10.1093/tropej/38.5.247
© 1992 by Oxford University Press
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Use of Hepatitis B Vaccine Alone or in Combination with Hepatitis B Immunoglobulin for Immunoprophylaxis of Perinatal Hepatitis B Infection

A. Sehgal*, R. Sehgal**, I. Gupta*,, O. N. Bhakoo*** and N. K. Ganguly{dagger}

*Departments of Obstetrics and Gynaecology, Postgraduate Institute of Medical Education and Research Chandigarh, India 160012
**Departments of Parasitology, Postgraduate Institute of Medical Education and Research Chandigarh, India 160012
***Departments of Paediatrics, Postgraduate Institute of Medical Education and Research Chandigarh, India 160012
{dagger}Departments of Experimenta1 Medicine, Postgraduate Institute of Medical Education and Research Chandigarh, India 160012

Dr Indu Gupta, Department of Obstetrics and Gynaecology, Pgimer, Chandigarh-160012, India.

The efficacy of hepatitis B vaccine alone or in combination with immonoglobulin in neonates born to HBsAG positive mothers was investigated. Twenty-four infants were given three doses (at 0, 1, 2 months) of the vaccine alone, while 27 infants were given hepatitis B immunoglobulia (HBIG) a d three doses of the vaccine. Fifty-eight infants born to HBsAg positive mothers who did not agree for vaccination or could not come for follow-up constituted the control group. The overall seroprotection rates (anti-HBS levels ≥ 10 IU/l) were almost similar in both the groups at 6 months (81 and 76 per cent, respectively). However, the seroprotection rates in babies born to HBeAg positive mothers were better with combination of HBIG and vaccine (71 v. 57 per cent, respectively). It was also observed that seroprotection rates in babies born to anti-HBe positive mothers were even better (100 and 90 per cent in vaccine alone aod combination group, respectively). No chronic carrier was detected in babies boro to anti-HBe positive motbers.


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C. Lee, Y. Gong, J. Brok, E. H Boxall, and C. Gluud
Effect of hepatitis B immunisation in newborn infants of mothers positive for hepatitis B surface antigen: systematic review and meta-analysis
BMJ, February 11, 2006; 332(7537): 328 - 336.
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