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Journal of Tropical Pediatrics 1992 38(4):162-166; doi:10.1093/tropej/38.4.162
© 1992 by Oxford University Press
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Assessment of Chloroquine Resistance of Plasmodium falciparum in children of Wad Medani (Central Sudan)

Adil M. Ibrahim, PhD, DIC, MIBiol*, Fath El Rahman A Ali, MRCP, MSc** and Mohi Eldin M. Ali, MBBS, MSc**

*Faculty of Science & Technology, University of Gezira PO Box 2667, Khartoum, Sudan
**Faculty of Medicine, University of Gezira PO Box 2667, Khartoum, Sudan

The study reports on chloroquine resistance of Plasmodium falciparum among Sudanese children (6 month to 16 years) living at Wad Medani, Central Sudan. AH RI-III levels of resistant response were confirmed, while in vitro sensitivity test indicated that 25 per cent of P. falciparum isolates examined had exhibited maturation of schizonts at CQ level ≥1.6 pmol/µl blood. CQ was sufficiently retained for 7 days after drug administration whereas an average peak level of CQ in blood (348 ng/ml) was recorded on day 1. Patients were successfully treated by an age-measured dose of parenteral quinine (10 mg/kg).


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