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Journal of Tropical Pediatrics 1992 38(4):149-152; doi:10.1093/tropej/38.4.149
© 1992 by Oxford University Press
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C-Reactive Protein in Measles

Irmeli Roine, MD*,, Walter Ledermann, MD*, Noemi Arrizaga, MD*, Pilar Bosch, MD*, Laura Bertin, MD**, Susana Urrutia, MD**, Antonio Banfi, MD* and Heikki Peltola, MD***

*Hospital Luis Calvo Mackenna Santiago, Chile
**Carol Urzua Health Center Penalolen Santiago, Chile
***Children's Hospital, University of Helsinki, and National Public Health Institute Helsinki, Finland

Correspondence: Irmeli Roine, Los Misioneros 2237, Santiago, Chile.

Seventy-two children with early measles (lst–3rd day of rash), presenting at two centres in Santiago, Chile, were classified as having mild (‘ordinary measles’, n = 50), or moderate to severe measles (‘primarily severe measles’, n = 22). The level of serum C-reactive protein (CRP) was determined by nephelometry from a finger prick sample. The mean CRP value in ordinary measles, 19 mg/l, was significantly lower (P<0.001) than in primarily severe measles where the mean CRP was 65 mg/l.

During late measles (5th–8th day of rash), the mean CRP was 19 mg/l if the child recovered uneventfully (n = 35), whereas the mean level of 123 mg/l (P<0.001) was encountered when the child suffered from complicating pneumonia (n = 22).

We conclude that the simple quantitative CRP determination is a useful alarm signal during the course of measles: elevated levels point to severity or complications in recovery.


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