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Journal of Tropical Pediatrics 1992 38(3):103-105; doi:10.1093/tropej/38.3.103
© 1992 by Oxford University Press
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Use of a Recombinant Antigen (OC 3.6 cDNA) for the Serological Diagnosis of Onchocerciasis in Exposed Nigerian Children

A. F. Ogunrinade*, R. Chandrashekar**, G. J. Weil** and O. O. Kale***

*Department of Veterinary Microbiology & Parasitology, University of Ibadan Ibadan, Nigeria
**Infections Diseases Unit, Washington University Medical Centre St Louis, MO, USA
***Department of Preventive & Social Medicine, College of Medicine, University of Ibadan Ibadan, Nigeria

We evaluated a recombinant antigen (OC 3.6 cDNA) expressed in pMAL TM vector for the diagnosis of onchocerciasis in children living in an endemic focus of forest-type onchocerciasis in Nigeria. Using the Western blot with the maltose-binding fusion protein as antigen, 91 per cent of mf-positive children and 24 per cent of endemic normal children were positive. Furthermore, age was not a limitation to the assay. The practical limitations of the assay for field diagnosis of onchocerciasis is discussed.


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