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Journal of Tropical Pediatrics 1991 37(5):226-231; doi:10.1093/tropej/37.5.226
© 1991 by Oxford University Press
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research-article

HLA Antigen Frequencies in Children with Cardiac Disease in Cairo

A. M. Eissa, MD, S. El-Tayeb, PhD and N. M. Nour, MD

Pediatrics and Clinical Pathology Departments, Al-Azhar University Cairo, Egypt

The study of Histocompatibility Locus Antigen (HLA) frequencies in 48 cases with congenital heart disease (CHD) in children in Cairo showed high incidence of A10.

Cases with atrial septal defect have shown a significant association with A3 besides A10.

There is also a significant association between B 12–45 and right loop anomalies (Fallot's and pulmonary stenosis) together with A10.

On the other hand, children with rheumatic heart disease have shown strong positive association with HLA group B12–45 and negative association with A28.


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