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Journal of Tropical Pediatrics 1987 33(5):254-256; doi:10.1093/tropej/33.5.254
© 1987 by Oxford University Press
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Protein Losing Enteropathy in the Different Forms of Protein-energy Malnutrition

E. H. Madina, MD, A. T. Soliman, MM Paed and M. R. Morsi, MD

Department of Paediatrics, University of Alexandria, Faculty of Medicine El-Chatby, Alexandria, Egypt

Correspondence: E. H. Madina, Department of Pediatrics, University of Alexandria, Faculty of Medicine, El-Chatby, Alexandria, Egypt.

Serum and faecal alpha-1 antitrypsin concentrations as well as alpha-1 antitrypsin clearance were measured in 10 children with kwashiorkor, 10 children with marasmus, 10 children with marasmic kwashiorkor, and 10 normal Egyptian children. Serum alpha-1 antitrypsin concentrations were significantly lower than normal in all the three severely malnourished groups. The intestinal clearance of alpha-1 antitrypsin was significantly higher in the marasmic and marasmic kwashiorkor groups suggesting an important role of protein-losing enteropathy in the pathogenesis of nutritional edema.


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