© 1987 by Oxford University Press
research-article |
Protein Losing Enteropathy in the Different Forms of Protein-energy Malnutrition
Department of Paediatrics, University of Alexandria, Faculty of Medicine El-Chatby, Alexandria, Egypt
Correspondence: E. H. Madina, Department of Pediatrics, University of Alexandria, Faculty of Medicine, El-Chatby, Alexandria, Egypt.
Serum and faecal alpha-1 antitrypsin concentrations as well as alpha-1 antitrypsin clearance were measured in 10 children with kwashiorkor, 10 children with marasmus, 10 children with marasmic kwashiorkor, and 10 normal Egyptian children. Serum alpha-1 antitrypsin concentrations were significantly lower than normal in all the three severely malnourished groups. The intestinal clearance of alpha-1 antitrypsin was significantly higher in the marasmic and marasmic kwashiorkor groups suggesting an important role of protein-losing enteropathy in the pathogenesis of nutritional edema.