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Journal of Tropical Pediatrics Advance Access published online on November 3, 2009
Journal of Tropical Pediatrics, doi:10.1093/tropej/fmp101
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© The Author [2009]. Published by Oxford University Press. All rights reserved. For Permissions, please email: journals.permissions@oxfordjournals.org

Haplotype of IL-8 -251T and 781C is associated with the Susceptibility to Respiratory Syncytial Virus

Aizhen Lu, Libo Wang and Xiaobo Zhang

Department of Respiratory Care, Children's Hospital of Fudan University, Shanghai 201102, China

Correspondence: Libo Wang, Medical doctor, Department of Respiratory Care, Children's; Hospital of Fudan University, Shanghai 201102, China. E-mail: <wanglbc{at}163.com>.


  Abstract

Objective: To study the association of haplotypes of IL-8 -251T/A and 781 C/T single nucleotide polymorphisms (SNPs) with the susceptibility of respiratory syncytial virus (RSV).

Methods: This study included 101 hospitalized patients under 2 years who suffered from RSV pneumonia and108 hospitalized patients under 2 years who suffered only from pneumonia without RSV infection. Genotypes of two SNP loci in all enrolled persons were defined by allele-specific polymerase chain reaction. The allele’s frequencies of SNPs were analyzed with case–control study, linkage of two loci and haplotypes composed by the two loci were also studied.

Results: (i) The frequency of IL-8 -251T in cases was dramatically high (OR = 2.08, p = 0.0002). (ii) Haplotype of TC was significantly high in cases (p = 0.01).

Conclusion: These findings support that haplotype of TC composed by IL-8 -251T and 781C is associated with the susceptibility of RSV.

Key Words: respiratory syncytial virus • association study • single nucleotide polymorphism • IL-8 • allele-specific polymerase chain reaction


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