Skip Navigation



Journal of Tropical Pediatrics Advance Access published online on October 12, 2009
Journal of Tropical Pediatrics, doi:10.1093/tropej/fmp098
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow E-letters: Submit a response
Right arrow Alert me when this article is cited
Right arrow Alert me when E-letters are posted
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrowRequest Permissions
Google Scholar
Right arrow Articles by Liu, J.
Right arrow Articles by Feng, Z.-C.
PubMed
Right arrow PubMed Citation
Right arrow Articles by Liu, J.
Right arrow Articles by Feng, Z.-C.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

© The Author [2009]. Published by Oxford University Press. All rights reserved. For Permissions, please email: journals.permissions@oxfordjournals.org

Increased Umbilical Cord Plasma Interleukin-1β Levels was Correlated with Adverse Outcomes of Neonatal Hypoxic-ischemic Encephalopathy

Jing Liu and Zhi-Chun Feng

Department of Neonatology and NICU Feng, Bayi Children’s Hospital Affiliated with Beijing Military Region General Hospital, Beijing 100700, China

Correspondence: Zhi-Chun Feng, Department of Neonatology and NICU, Bayi Children's Hospital Affiliated with Beijing Military Region General Hospital, Beijing 100700, China. Tel.: +86-10-66721257. E-mail: <liujingbj{at}live.cn>.


  Abstract

To explore whether or not the umbilical blood levels of cytokines can be used to indicate the adverse outcomes of hypoxic-ischemic encephalopathy (HIE) patients. Umbilical artery blood and peripheral venous blood samples were collected on the 1st, 3rd and 7th days after birth to detect the levels of IL-1β, IL-8 and TNF-{alpha}. Neurological examination and Denver developmental screening test (DDST-II) were performed at the 6 and 12 months evaluations to detect any neurodevelopmental abnormalities. The results showed: (i) the serum concentrations of IL-1β, IL-8 and TNF-{alpha} in umbilical and peripheral blood were significantly higher in HIE patients than control groups; (ii) the umbilical blood concentrations of IL-1β exhibited the best positive correlation with HIE grades, when compared with IL-8 and TNF-{alpha}; and (iii) abnormal neurological outcomes at 6 and 12 months of age were best predicted by umbilical levels of IL-1β. Thus, umbilical concentrations of IL-1β were associated with the grades and adverse outcomes of HIE.


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?




Disclaimer: Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.