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Journal of Tropical Pediatrics Advance Access published online on October 9, 2009
Journal of Tropical Pediatrics, doi:10.1093/tropej/fmp094
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© The Author [2009]. Published by Oxford University Press. All rights reserved. For Permissions, please email: journals.permissions@oxfordjournals.org

Assessment of Cardiac Functions in Sickle Cell Anemia with Doppler Myocardial Performance Index

Ali Ertug Arslankoylua, Olgu Hallioglub, Esat Yilgorc and Oznur Duzovalic

aDepartment of Pediatric Intensive Care
bDepartment of Pediatric Cardiology
cDepartment of Pediatrics, Faculty of Medicine, Mersin University, Mersin, Turkey

Correspondence: Dr. Ali Ertug Arslankoylu, Mersin University Faculty of Medicine, Department of Pediatrics, Pediatric Intensive Care Unit. 33079, Mersin, Turkey. Tel.: +90 324 3374300-1161; Fax: +90 324 3374305. E-mail: <aliertug{at}gmail.com>.


  Abstract

Background: The purpose of this study was to evaluate left and right ventricular functions by using the Doppler myocardial performance index (MPI), in children with sickle cell anemia (SCA).

Methods: We examined 32 patients with SCA and 30 age-matched healthy children. Echocardiography and Doppler examinations were completed for each of the subjects. MPI was calculated from the Doppler tracings.

Results: Compared with controls, left ventricle (LV) end-diastolic diameter, end-systolic diameter, early-diastolic mitral flow velocity and late-diastolic mitral flow velocity were significantly higher in the patients with SCA. Although, the LV ejection fractions were in the normal ranges in patients and controls, both LV and right ventricle (RV) MPI were significantly higher in patients than those in normal children.

Conclusion: MPI may be a useful noninvasive and sensitive tool for assessing the sub-clinical cardiac LV and RV dysfunctions in patients with SCA.


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