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Journal of Tropical Pediatrics Advance Access published online on October 1, 2009
Journal of Tropical Pediatrics, doi:10.1093/tropej/fmp093
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© The Author [2009]. Published by Oxford University Press. All rights reserved. For Permissions, please email: journals.permissions@oxfordjournals.org

Do Children with Adenotonsillar Hypertrophy have Lower IGF-1 and Ghrelin Levels than the Normal Children?

Tolga Sena and Abdullah Ayçiçekb

aDepartment of Pediatrics/Pediatric Endocrinology, Faculty of Medicine, Afyon Kocatepe University, Afyonkarahisar 03200, Turkey and bDepartment of Otorhinolaryngology, Faculty of Medicine, Afyon Kocatepe University, Afyonkarahisar 03200, Turkey

Correspondence: Tolga Sen, Department of Pediatrics, Faculty of Medicine, Afyon Kocatepe University, Afyonkarahisar 03200, Turkey. E-mail: <tolgasen69{at}yahoo.com>.

Abstract


  Abstract

Objective: This study was designed to determine serum insulin-like growth factor-1 (IGF-1) and plasma ghrelin levels in male children with adenoid and tonsillar hypertrophy and compare them with healthy controls.

Methods: This study included 29 male prepubertal children between the ages of 6.5 and10 years (mean age 8.8 ± 2.5 years) with obstructive adenoid and tonsillar hypertrophy and 20 normal male controls between the ages of 5.7 and 10.8 years (mean age 8.2 ± 2.9 years). Plasma ghrelin and serum IGF-1 levels were measured at 8.30, in the morning.

Results: Children with adenoid and tonsillar hypertrophy had significantly depressed serum IGF-1 levels (203 ± 150 ng ml–1) and plasma ghrelin levels (175 ± 66 pg ml–1) compared with healthy controls (354 ± 242 ng ml–1 and 243 ± 93 pg ml–1, respectively, P < 0.05).

Conclusion: Depressed levels of ghrelin in children with adenoid and tonsillar hypertrophy lead to decreased appetite and insufficient energy intake. Lower serum levels of IGF-1 in children with adenoid and tonsillar hypertrophy may be secondary to deficient growth hormone stimulation by ghrelin.


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