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Journal of Tropical Pediatrics Advance Access published online on August 5, 2009
Journal of Tropical Pediatrics, doi:10.1093/tropej/fmp074
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© The Author [2009]. Published by Oxford University Press. All rights reserved. For Permissions, please email: journals.permissions@oxfordjournals.org

Brief Report

Detection of Artemisinin-resistant Plasmodium falciparum in Malarial Infection: A Brief Review of Methods

Neils B. Quashiea,b

a Division of Infection and Immunity, Institute of Biomedical and Life Sciences, Glasgow Biomedical Research Centre, University of Glasgow, 120 University Place, Glasgow G12 8TA, UK
b Centre for Tropical Clinical Pharmacology and Therapeutics, University of Ghana Medical School, PO. Box GP 4236, Accra, Ghana

Correspondence: Neils B. Quashie, Division of Infection and Immunity, Institute of Biomedical and Life Sciences, Glasgow Biomedical Research Centre, University of Glasgow, 120 University Place, Glasgow G12 8TA, UK. Tel.: +44 7947749374; E-mail: <N.Quashie{at}bio.gla.ac.uk>.


  Abstract

The WHO has recommended artemisinin-based combination therapy (ACT) for the treatment of malaria in disease endemic countries. In an attempt to assess the sensitivity of Plasmodium falciparum to the drug, various methods have been used. It is the purpose of this short review to critically examine these methods and give recommendations.

Key Words: Artemisinin • resistance • Plasmodium falciparum • combination • parasite • mutation


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