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Journal of Tropical Pediatrics Advance Access published online on July 16, 2009
Journal of Tropical Pediatrics, doi:10.1093/tropej/fmp060
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© The Author [2009]. Published by Oxford University Press. All rights reserved. For Permissions, please email: journals.permissions@oxfordjournals.org

Risk Factors for Extended-Spectrum β-Lactamase Producing Escherichia Coli and Klebsiella Pneumoniae Acquisition in a Neonatal Intensive Care Unit

S. Shakila *, S. Z. Alia *, M. Akrama, S. M. Alib and A. U. Khana *

aInterdisciplinary Biotechnology Unit, Aligarh Muslim University Aligarh, India
bDepartment of Pediatrics, JNMC Hospital, Aligarh, India

Correspondence: A. U. Khan, Interdisciplinary Biotechnology Unit, Aligarh Muslim University, Aligarh 202 002, India. Tel.: 0091-9837021912, Fax: 0091-571-2721776, E-mail: <asad.k{at}rediffmail.com>; <asadukhan72{at}gmail.com>.


  Abstract

This study was made to find the prevalence of extended-spectrum β-lactamase (ESBL)-producing Escherichea coli and Klebsiella pneumoniae in neonatal intensive care unit (NICU) and to identify the risk factors associated with the acquisition of these organisms. Risk factors associated with ESBL-producing E. coli and/or K. pneumoniae acquisition status of neonates were assessed. Of 253 neonates admitted, 238 entered the active surveillance system. ESBL-producing K. pneumoniae was responsible for 7 infections and 51 colonizations while ESBL-producing E. coli was responsible for 9 infections and 88 colonizations. Concurrent isolation of both the organisms occurred in 30 neonates. The logistic regression model identified ‘length of stay in the NICU’ as the single independent risk factor. Imipenem, cefepime and amikacin can be suggested as the drugs of choice in our study.

*These authors contributed equally to this work.


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