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Journal of Tropical Pediatrics Advance Access published online on May 15, 2009
Journal of Tropical Pediatrics, doi:10.1093/tropej/fmp034
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© The Author [2009]. Published by Oxford University Press. All rights reserved. For Permissions, please email: journals.permissions@oxfordjournals.org

Brief Report

Relationship of CD4+ T-cell counts and plasma HIV-1 RNA levels with serological HBeAg/anti-HBe patterns obtained in West-African HBV-HIV-1-co-infected children

François Roueta, Marie-Laure Chaixb, Alphonse Kpozehouenc, André Inwoleya, Marie-France Anakyd, Patricia Fassinoue, Christine Rouziouxb, Stéphane Blanchef and Philippe Msellatig

aCeDReS, CHU de Treichville, Abidjan, Côte d’Ivoire
bUniversité Paris Descartes EA 3620, Laboratoire de Virologie, AP-HP, C.H.U. Necker-Enfants Malades, Paris, France
cCentre de calcul, Centre Muraz, Bobo-Dioulasso, Burkina Faso
dProgramme ANRS 1244/1278 Enfant Yopougon, PAC-CI, Abidjan, Côte d’Ivoire
eService de Pédiatrie, CHU de Yopougon, Abidjan, Côte d’Ivoire
fUniversité Paris Descartes EA 3620, Service d’Immunologie et d’Hématologie Pédiatrique, AP-HP, C.H.U. Necker-Enfants Malades, Paris, France
gCrecSS (Centre de Recherche Cultures Santé Société)/IFEHA, Université Paul Cezanne, Aix en Provence, France

Correspondence: François Rouet, PharmD, PhD, Laboratoire de Virologie – Centre Muraz, Avenue Mamadou Konaté, 01 BP390 Bobo-Dioulasso 01, Burkina Faso. Tel: +226 20 97 01 02; Fax: +226 20 97 04 57; E-mail <franrouet{at}yahoo.fr>.


  Abstract

HBeAg/anti-HBe and hepatitis B virus (HBV) DNA from 34 HIV-1-infected children from Ivory Coast with chronic hepatitis B (CHB) were longitudinally analyzed according to CD4 and HIV-1 RNA. The mean CD4% value was significantly (p = 0.03) lower in 59 (52.7%) samples showing a usual CHB (HBeAg-positive/anti-HBe-negative and HBV DNA-positive), as compared with 30 (26.8%) HBeAg-positive/anti-HBe-positive and HBV DNA-positive and 23 (20.5%) HBeAg-negative/anti-HBe-positive and HBV DNA-negative (15.1% vs. 18.5% and 20.0%). The mean HIV-1 RNA concentrations were significantly (p = 0.01) higher in specimens HBV DNA-positive (4.47 and 4.30 log10/ml, respectively) vs. HBV DNA-negative (3.43 log10/ml). HIV-1 has a significant impact on CHB acquired in childhood.

Key Words: Africa • children • HBV • HIV


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