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Journal of Tropical Pediatrics Advance Access published online on April 20, 2009
Journal of Tropical Pediatrics, doi:10.1093/tropej/fmp029
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© The Author [2009]. Published by Oxford University Press. All rights reserved. For Permissions, please email: journals.permissions@oxfordjournals.org

Brief Report

Subtyping and env C2/V3 Sequence Analysis of HIV-1 Isolated from HIV-Infected Children Hospitalized in Children Hospital 1, Vietnam during 2004–2005

Quang Duy Trinha, Ngan Thi Kim Phama, Bao Quoc Lamb, Thoa Phan Kim Leb, Khanh Huu Truongb, Thinh Quoc Leb, Hung Thanh Vob, Thuong Chi Tangb, Tuan Manh Hac, Yasuyuki Izumid, Masashi Mizuguchia, Satoshi Hayakawad and Hiroshi Ushijimae

aDepartment of Developmental Medical Sciences, Institute of International Health, Graduate School of Medicine, the University of Tokyo, Japan
bChildren's Hospital 1, Ho Chi Minh City, Vietnam
cChildren's Hospital 2, Ho Chi Minh City, Vietnam
dDivision of Microbiology, Department of Pathology and Microbiology, Nihon University School of Medicine, Tokyo, Japan
eAino Health Science Center and Aino University, Tokyo, Japan

Correspondence: Hiroshi Ushijima, MD, PhD, Aino Health Science Center, Aino University, 2-17-3 Shibuya, Shibuya-ku, Tokyo 150-0002, Japan. E-mail: <ushijima-hiroshi{at}jcom.home.ne.jp>.


  Abstract

A molecular epidemiological study was conducted on 104 HIV-1 strains isolated from HIV-infected children hospitalized in Children Hospital 1 in Ho Chi Minh City, Vietnam during 2004–2005. Genetic subtyping based on env C2/V3 sequences revealed that CRF01-AE was the sole circulating recombinant form found in this study. Sequence analysis of the V3 loop showed that GPGQ tetramer was the most common V3 loop core motif identified in the HIV-1 strains studied (89.5%). The findings raise great concern about HIV-infected children in Vietnam and provide up-to-date molecular epidemiological information of HIV-1 circulating in Vietnam during the study period.

Key Words: HIV-1 • HIV-infected children • Vietnam


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