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Journal of Tropical Pediatrics Advance Access published online on April 20, 2009
Journal of Tropical Pediatrics, doi:10.1093/tropej/fmp025
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© The Author [2009]. Published by Oxford University Press. All rights reserved. For Permissions, please email: journals.permissions@oxfordjournals.org

Oxidative Stress and Antioxidant Status in Neonates Born to Pre-eclamptic Mother

Md. Zakir H. Howladera, Sayma Parveena, Sonia Tamannaa, Tanzir A. Khanb and Firoza Begumc

aDepartment of Biochemistry and Molecular Biology, University of Dhaka, Dhaka-1000, Bangladesh
bIFST, Bangladesh Council of Scientific and Industrial Research (BCSIR), Dhaka, Bangladesh
cDepartment of Obstetrics and Gynecology, Bangabandhu Sheikh Mujib Medical University (BSMMU), Dhaka, Bangladesh

Correspondence: M. Z. H. Howlader, Department of Biochemistry and Molecular Biology, University of Dhaka, Dhaka-1000, Bangladesh. E-mail: <hhzakir{at}yahoo.com>.


  Abstract

Objective: Pre-eclampsia is a significant health problem and is the leading cause of maternal and perinatal mortality and morbidity. Low birth weight and prematurity are very common in pre-eclamptic mothers. Pre-eclampsia is associated with oxidative stress in the maternal circulation. To observe the effect of pre-eclampsia on neonates, this study was designed to explore oxidative stress and anti-oxidant status in the fetal circulation in pre-eclampsia.

Materials and Methods: For this purpose, we collected cord bloods during delivery from Bangabandhu Sheikh Mujib Medical University. Twenty samples were collected from uncomplicated (normotensive) mothers and 15 samples were collected from pre-eclamptic mothers (maternal age matched). Thiobarbituric acid reactive substances (TBARS), lipid hydroperoxide, protein carbonyl value, lipid profile, total anti-oxidant status (TAS), vitamin C, serum total protein and albumin were measured.

Results: It was observed that TBARS and lipid hydroperoxide were significantly (P < 0.001) increased, protein carbonyl content were also significantly (P < 0.001) increased but total anti-oxidant status (P < 0.001) and vitamin C level were significantly (P < 0.05) decreased in cord blood from pre-eclamptic mother compared to control group. Cholesterol, TG, LDL level was elevated and HDL were lowered in cord blood in pre-eclamptic group compared to normotensive group. In pre-eclamptic group, cord blood total protein, albumin and globulin level were significantly decreased compared to control group.

Conclusions: As pre-eclampsia is associated with increased oxidative stress and decreased anti-oxidant status, the results of these investigations suggest that oxidative stress and antioxidant status are altered towards proatherogenic level in cord blood of pre-eclamptic women which may ultimately be responsible for different complications of newborn babies of pre-eclamptic mothers.

Key Words: pre-eclampsia • cord blood • oxidative stress • neonates


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