Journal of Tropical Pediatrics Advance Access published online on December 21, 2007
Journal of Tropical Pediatrics, doi:10.1093/tropej/fmm105
Hypertriglyceridemic Waist Phenotype and Associated Lifestyle Factors in a National Population of Youths: CASPIAN Study
aLiver and Gastrointestinal Research Center, Baqiyatallah University of Medical Sciences,Tehran, Iran
bBureau of Family Health, Ministry of Health and Medical Education, Tehran, Iran
cYouth & School Health Office, Ministry of Health and Medical Education, Tehran, Iran
dBureau of Health, Ministry of Education, Tehran, Iran
eIsfahan University of Medical Sciences, Isfahan, Iran
fPreventive Pediatric Cardiology Department, Isfahan Cardiovascular Research Center, Isfahan University of Medical Sciences, Isfahan, Iran
Correspondence: Dr Roya Kelishadi, Preventive Pediatric Cardiology Department, Isfahan Cardiovascular Research Center (WHO-Collaborating Center in EMR), Isfahan University of Medical Sciences, PO.Box: 81465-1148, Isfahan, Iran +98-311-3377881-8; +98-311-3373435; E-mail < kroya{at}aap.net>.
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Abstract |
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The objectives of the current study, that is the first of its kind, were to determine the prevalence of the hypertriglyceridemic waist (HW) phenotype in a nationally representative sample of children, as well as the metabolic risk factors identified by HW, and to identify lifestyle habits related to this phenotype. This national survey was conducted on 4811 representative school-students. We assessed the sensitivity and specificity of the HW phenotype for abnormal anthropometric and biochemical factors by using receiver operator characteristic curves. We determined the association of dietary patterns (obtained by factor analysis), physical activity level and some environmental factors with the HW phenotype. Overall, 8.52% of participants had the HW phenotype. Those children with the HW phenotype were more likely to have cardiovascular risk factors, notably for overweight and hypercholesterolemia. The dietary pattern characterized by junk foods increased the odds of having the HW phenotype, OR = 1.426 (95%CI, 1.109, 1.892), whereas the other dietary pattern including healthy foods decreased this odds, OR = 0.874 (95%CI, 0.765, 0.998). The risk of the HW phenotype rose with the consumption of solid hydrogenated fat as well as white-flour bread. Low education of parents and a positive family history of diabetes mellitus, obesity and or premature cardiovascular disease were the other risk factors for the HW phenotype. Low levels of physical activity significantly increased the risk of having the HW phenotype. The HW phenotype can be used as an accurate and easy tool for screening children at metabolic risk in population-based studies.
Key Words: Hypertriglyceridemia • abdominal obesity • metabolic risk factors • population-based survey • determinants • lifestyle habits