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Journal of Tropical Pediatrics Advance Access originally published online on December 18, 2008
Journal of Tropical Pediatrics 2009 55(3):205-207; doi:10.1093/tropej/fmn112
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© The Author [2008]. Published by Oxford University Press. All rights reserved. For Permissions, please email: journals.permissions@oxfordjournals.org

Case Reports

Psychotic Disorder and Extrapyramidal Symptoms Associated with Vitamin B12 and Folate Deficiency

Murat Dogana, Osman Ozdemirb, Ertan A. Salc, S. Zehra Doganc, Pinar Ozdemirb, Yasar Cesura and Hüseyin Caksend

aDepartment of Pediatric Endocrinology, YYU Medicine Faculty
bDepartment of Psychiatry, YYU Medicine Faculty
cDepartment of Pediatrics, YYU Medicine Faculty
dDepartment of Pediatric Neurology, YYU Medicine Faculty

Correspondence: Murat Dogan. E-mail: <doganmurat.md{at}gmail.com>.


  Abstract

Vitamin B12 and folate deficiency causing neuropsychiatric and thrombotic manifestations, such as peripheral neuropathy, subacute combined degeneration of cord, dementia, ataxia, optic atrophy, catatonia, psychosis, mood disturbances, myocardial infarction and portal vein thrombosis are well known. This present report highlights an unusual presentation of vitamin B12 deficiency—psychotic disorder, extrapyramidal symptoms in a 12-year-old boy. His symptoms responded to parenteral vitamin B12 therapy. So with this report we emphasized that serum vitamin B12 and folate levels should be measured, especially in those patients who present with other known neuropsychiatric features of vitamin B12 and folate deficiency.

Key Words: Vitamin B12 • folate deficiency • psychotic disorder • extrapyramidal symptoms


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