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Journal of Tropical Pediatrics Advance Access originally published online on November 20, 2008
Journal of Tropical Pediatrics 2009 55(2):135-137; doi:10.1093/tropej/fmn095
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© The Author [2008]. Published by Oxford University Press. All rights reserved. For Permissions, please email: journals.permissions@oxfordjournals.org

Brief Reports

A Visual Dosing Aid for First-line Pediatric Antiretroviral Treatment in Resource-poor Settings

Steven F. J. Callensa, Daniel Westreicha, Faustin Kiteteleb, Jean Lusiamab, Nicole Shabanib, Tom Belhornc, Robert Colebundersd, Frieda Behetsa and Annelies Van Riea

aSchool of Public Health, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA
bSchool of Public Health, University of Kinshasa, Kinshasa, Democratic Republic of the Congo
cDepartment of Pediatrics, Division of Pediatric Infectious Diseases and Immunology, School of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA
dUniversity of Antwerp and Institute of Tropical Medicine, Antwerp, Belgium

Correspondence: Steven F. J. Callens, 2102-D McGavran-Greenberg Hall, School of Public Health, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599-7435, USA. Tel.: + 1 919-966-7430; Fax: + 1 919-966-2089. E-mail: <callens{at}email.unc.edu>


  Abstract

The visual dosing aid (VDA) was developed to facilitate dosing calculations in response to children's; growth and weight during antiretroviral treatment. The theoretical accuracy of the VDA was assessed using anthropometric data from 55 children receiving care in the USA and 324 children in the Democratic Republic of the Congo. The VDA dose was similar to the WHO recommended dose. A potentially significant relative dosing difference of ≥20% occurred in <3% of children for NVP, AZT and d4T, but was observed in 20% for 3TC, overdosing being more frequent. The VDA compared well with generic pediatric fixed dose combination tablets. Results did not differ between sites. The VDA enables accurate dosing of pediatric ART in distinct populations and could facilitate roll-out of pediatric ART in resource-poor settings.

Key Words: children • resource-poor setting • antiretroviral treatment • drug dosing


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