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Journal of Tropical Pediatrics Advance Access originally published online on November 29, 2007
Journal of Tropical Pediatrics 2009 55(1):26-31; doi:10.1093/tropej/fmm100
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© The Author [2007]. Published by Oxford University Press. All rights reserved. For Permissions, please email: journals.permissions@oxfordjournals.org

Pre-exposure Purified Vero Cell Rabies Vaccine and Concomitant Routine Childhood Vaccinations: 5-year Post-vaccination Follow-up Study of an Infant Cohort in Vietnam

Jean Langa, Emmanuel Feroldia and Nguyen Cong Vienb

aSanofi Pasteur, Marcy L'etoile, France
bCenter of Pediatrics, Development and Health, Children's Hospital No. 2, Ho Chi Minh City, Vietnam

Correspondence: Jean Lang, Sanofi Pasteur 1541, Avenue Marcel Merieux 69280, Marcy l'Etoile, France. E-mail <jean.lang{at}sanofipasteur.com>.


  Abstract

Children have a high risk of exposure to rabies in countries where the disease is endemic. This prospective, 5-year study followed two groups of children who had received diphtheria, tetanus, whole-cell pertussis and inactivated poliomyelitis vaccine (DTP-IPV) at 2, 3, 4 months and 1 year (Group B) or concomitant with three doses of purified Vero cell rabies vaccine (PVRV), given at 2, 4 months and 1 year (Group A). Antibody determinations were made annually for 5 years. Data were available from a total of 72 subjects; 30 in Group A and 32 in Group B. In Group A, the percentage of patients immunized against rabies (anti-rabies ≥ 0.5 IU/ml) decreased from 100% after the third vaccination to 63%, 5 years later. After 5 years, 93.8% in Group A and 96.7% in Group B had seroprotective diphtheria antibody titers ≥ 0.01 IU/ml, and all subjects had anti-polio (type 1, 2 and 3) seroprotective titers ≥ 5 1:dil. We conclude that co-administration of PVRV with DTP-IPV elicited protective antibody concentrations to all antigens that persist for at least 5 years, with continued protection against rabies in over 60% of subjects. These results are consistent with integration of pre-exposure rabies vaccination into the Expanded Program on Immunization (EPI) in countries where rabies is endemic.

Key Words: concomitant DTP-IPV • Expanded Program of Immunization • intramuscular • purified Vero cell rabies vaccine • rabies pre-exposure immunization • routine childhood vaccination


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