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Journal of Tropical Pediatrics Advance Access originally published online on March 10, 2006
Journal of Tropical Pediatrics 2006 52(4):296-298; doi:10.1093/tropej/fml001
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© The Author [2006]. Published by Oxford University Press. All rights reserved. For Permissions, please email: journals.permissions@oxfordjournals.org

Case Report

Recurrent Salmonella Bacteremia in Interleukin-12 Receptor ß1 Deficiency

Metehan Ozena, Mehmet Ceyhanb, Ozden Sanalc, Mehmet Bayraktard and Lütfiye Mescie

a Inonu University, Faculty of Medicine, Division of Pediatric Infectious Disease, Malatya, Turkey
b Hacettepe University, Faculty of Medicine, Unit of Pediatric Infectious Disease, Ankara, Turkey
c Hacettepe University, Faculty of Medicine, Unit of Pediatric Immunology, Ankara, Turkey
d Inonu University, Faculty of Medicine, Department of Clinical Microbiology, Malatya, Turkey
e Hacettepe University, Faculty of Medicine, Unit of Pediatric Immunology, Ankara, Turkey

Correspondence: Metehan Ozen, Ozalper Mah, Yasam Sitesi, C-Blok, No: 8, Malatya, Turkey. E-mail <metehanoz{at}yahoo.com>.

Interleukin-12 receptor ß1 (IL12RB1) deficiency causes vulnerability to poorly virulent mycobacteria and nontyphoid Salmonella species. We describe a 2.5 year-old girl with IL12RB1 deficiency, caused by a homozygous mutation in this gene, who presented with recurrent bacteremia caused by Salmonella spp.


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