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Journal of Tropical Pediatrics Advance Access originally published online on January 26, 2005
Journal of Tropical Pediatrics 2005 51(2):98-101; doi:10.1093/tropej/fmh087
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© Oxford University Press 2005; all rights reserved

Original Papers

High-dose Intravenous Immunoglobulin Downregulates the Activated Levels of Inflammatory Indices Except Erythrocyte Sedimentation Rate in Acute Stage of Kawasaki Disease

Kyung-Yil Lee, Hyung-Shin Lee, Ja-Hyun Hong, Ji-Whan Han, Joon-Sung Lee and Kyung-Tai Whang

Department of Pediatrics, College of Medicine, The Catholic University of Korea, Seoul, Republic of Korea

Kyung-Yil Lee, Department of Pediatrics, The Catholic University of Korea, Daejeon St. Mary's Hospital, 520–2 Daeheung-dong, Jung-gu, Daejeon 301–723, Republic of Korea. E-mail <leekyungyil{at}catholic.ac.kr>.

We evaluated the effects of high-dose intravenous immunoglobulin (IVIG) administration on various protein parameters, including inflammatory profiles, in children with Kawasaki disease (KD). Sixty-three children with KD were treated with IVIG at 2 g/kg over 12 h. Serial examinations of laboratory indices were performed three times: before IVIG treatment, 24 h after IVIG treatment, and 7 days after IVIG treatment. The white blood cell and neutrophil counts showed significant decreases 24 h and 7 days after IVIG administration. The erythrocyte sedimentation rate (ESR) increased significantly 24 h after IVIG, and the elevated level was sustained for 7 days. The levels of hemoglobin, albumin and inflammation-associated proteins, including C-reactive protein, decreased 24 h after IVIG treatment. Inflammation-associated proteins, except transferrin, decreased further to near normal levels after 7 days. On the other hand, IgM and IgA were not affected after 24 h, rather increased significantly after 7 days. High-dose IVIG causes immediate changes in the levels of various proteins, except IgA and IgM, and downregulates the activated levels of inflammatory indices, except ESR, in the acute stage of KD.


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