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Journal of Tropical Pediatrics 2004 50(2):94-97; doi:10.1093/tropej/50.2.94
© 2004 by Oxford University Press
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CD4+ and CD8+ T-lymphocyte Subsets in Zambian Children

Zaza Ndhlovu1, Judith J. Ryon2, Diane E. Griffin2, Mwaka Monze1, Francis Kasolo1 and William J. Moss2,3,*

1 Virology Laboratory, University Teaching Hospital, Lusaka, Zambia 2 W. Harry Feinstone Department of Molecular Microbiology and Immunology 3 Department of International Health, Bloomberg School of Public Health, Johns Hopkins University, Baltimore,Maryland, USA

Age-related changes in lymphocyte subsets in HIV-uninfected Zambian children are described.The total lymphocyte count and numbers of CD4+ and CD8+ T-lymphocytes declined with increasing age, while the percentage of CD4+ and CD8+ T-lymphocytes changed little during childhood. Girls between the ages of 12 and 71 months had a higher percentage of CD4+ T-lymphocytes and a higher CD4:CD8 ratio than did boys of a similar age.

* Correspondence: Dr William J. Moss, W. Harry Feinstone Department of Molecular Microbiology and Immunology, Bloomberg School of Public Health, Johns Hopkins University, 615 North Wolfe Street, Baltimore, Maryland, 21205-2179, USA. Tel. 410-955-3859; Fax 410-955-0105. E-mail <wmoss{at}jhsph.edu>.


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