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Journal of Tropical Pediatrics 2003 49(1):13-16; doi:10.1093/tropej/49.1.13
© 2003 by Oxford University Press
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Cerebrospinal Fluid Lysozyme Level for the Diagnosis of Tuberculous Meningitis in Children

O. P. Mishra1, P. Batra1, Z. Ali2, S. Anupurba3 and B. K. Das1

1 Department of Pediatrics, Institute of Medical Sciences, Banaras Hindu University, Varanasi, India 2 Department of Biochemistry, Institute of Medical Sciences, Banaras Hindu University, Varanasi, India 3 Department of Microbiology, Institute of Medical Sciences, Banaras Hindu University, Varanasi, India

Lysozyme activity was assayed in the cerebrospinal fluid (CSF) of 32 tuberculous meningitis (TBM), 17 bacterial meningitis, 10 partially treated bacterial meningitis, 18 encephalitis and 18 control subjects. The mean CSF lysozyme activity was significantly raised (p < 0.001) in TBM patients compared with other study groups. A cut-off CSF lysozyme level of ≥ 26 U/l had a sensitivity and specificity of 93.7 and 84.1 per cent, respectively for the diagnosis of TBM. Overall, it was found to be a better test than any other single test and thus can be used for rapid and early diagnosis of TBM in children.


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