Skip Navigation

Journal of Tropical Pediatrics 2002 48(6):351-353; doi:10.1093/tropej/48.6.351
© 2002 by Oxford University Press
This Article
Right arrow Full Text (PDF)
Right arrow E-letters: Submit a response
Right arrow Alert me when this article is cited
Right arrow Alert me when E-letters are posted
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in ISI Web of Science
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrow Search for citing articles in:
ISI Web of Science (6)
Right arrowRequest Permissions
Google Scholar
Right arrow Articles by Kutluk, G.
Right arrow Articles by Basak, M.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Kutluk, G.
Right arrow Articles by Basak, M.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

Comparisons of Oral Calcium, High Dose Vitamin D and a Combination of These in the Treatment of Nutritional Rickets in Children

Günsel Kutluk1, Feyzullah Çetinkaya1 and Muzaffer Basak1

1 Pediatrician, Sisli Etfal Education and Research Hospital, Istanbul, Turkey

Nutritional rickets remains a common child health problem in Turkey and many other developing countries. Although vitamin D deficiency is accepted as the basic problem underlying the disease, others postulate that a deficiency of dietary calcium, rather than vitamin D, is often responsible for the nutritional rickets in sunny countries. We conducted a placebo-controlled study to determine the best treatment regimen for nutritional rickets in children residing in lower socioeconomic regions of a sunny city, Istanbul. Forty-two infants (aged 6–30 months) with rickets were divided into three groups and included in the study. In a randomized fashion vitamin D (300 000 units, intramuscularly), calcium lactate (3 g daily) or a combination of vitamin D and calcium were given to the children. Alkaline phosphatase, calcium, albumin, ionized calcium and phosphorus levels were measured each week. X-ray examinations of the left wrist and left knee were undertaken at the beginning of the study and were repeated at the 2nd and 4th weeks and were scored in order to assess the response to treatment. Treatment produced an increase in serum calcium and a decrease in alkaline phosphatase concentration in all three groups, but the most important increase was reached in the vitamin D plus calcium group. We conclude that vitamin D deficiency appears to be the primary etiologic factor of rickets in our study group, but a better response to treatment with vitamin D or in combination with calcium was obtained than to treatment with calcium alone.


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?


This article has been cited by other articles:


Home page
 J. Nutr.Home page
I. H. Rosenberg
Interdepartmental Committee on Nutrition for National Defense Surveys in Asia and Africa
J. Nutr., May 1, 2005; 135(5): 1272 - 1275.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Clin. Nutr.Home page
M. Graff, T. D Thacher, P. R Fischer, D. Stadler, S. D Pam, J. M Pettifor, C. O Isichei, and S. A Abrams
Calcium absorption in Nigerian children with rickets
Am. J. Clinical Nutrition, November 1, 2004; 80(5): 1415 - 1421.
[Abstract] [Full Text] [PDF]

Home page
 Arch. Dis. Child.Home page
J Allgrove
Is nutritional rickets returning?
Arch. Dis. Child., August 1, 2004; 89(8): 699 - 701.
[Full Text] [PDF]


Disclaimer:
Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.