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Journal of Tropical Pediatrics 2002 48(2):113-116; doi:10.1093/tropej/48.2.113
© 2002 by Oxford University Press
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Brief Report

Clinico-haematological Profile of Pure Red Cell Aplasia in Children

R. K. Marwaha1, Deepak Bansal1, Amita Trehan1, Neelam Marwaha2 and Neelam Varma3

1 Division of Pediatric Hematology-Oncology, Advanced Pediatric Center Chandigarh, India 2 Department of Hematology and Blood Transfusion, Government Medical College Hospital, Chandigarh, India 3 Department of Hematology, Postgraduate Institute of Medical Education and Research, Chandigarh, India

Pure red cell aplasia (PRCA) is a rare disorder, characterized by isolated failure of erythropoiesis. The clinico-haematological profile of 16 patients with PRCA is presented in this communication. Fourteen patients had Diamond-Blackfan anaemia (DBA), one had transient erythroblastopenia of childhood, and one patient had PRCA secondary to carbamazepine. Physical abnormalities were observed in 50 per cent of patients with DBA. Of the nine patients with DBA who were administered prednisolone and had a regular follow-up, four (44.4 per cent) had no response, three (33.3 per cent) responded fully, and two (22.2 per cent) were steroid dependent.


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